Title : Efficacy of the third-generation bisphosphonate risedronate alone and in combination with anticancer drugs against osteosarcoma cell lines.

Pub. Date : 2008 Jul-Aug

PMID : 18751388






2 Functional Relationships(s)
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1 RESULTS: Risedronate inhibited both prenylation of Rap1A and Ras and phosphorylation of Erk 1 and 2 at a dose of 50 microM for 48 h. Treatment with risedronate induced significant time- and dose-dependent cytotoxicity in the LM8 cell line. Risedronic Acid mitogen-activated protein kinase 3 Homo sapiens
2 RESULTS: Risedronate inhibited both prenylation of Rap1A and Ras and phosphorylation of Erk 1 and 2 at a dose of 50 microM for 48 h. Treatment with risedronate induced significant time- and dose-dependent cytotoxicity in the LM8 cell line. Risedronic Acid mitogen-activated protein kinase 3 Homo sapiens