Pub. Date : 2008 Jul-Aug
PMID : 18751369
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RET activation inhibits doxorubicin-induced apoptosis in SK-N-MC cells. | sk-n-mc | ret proto-oncogene | Homo sapiens |
| 2 | MATERIALS AND METHODS: Each RET isoform was separately expressed in SK-N-MC cells (neural crest-derived tumor) and the impact of RET activation on doxorubicin-induced apoptosis was examined. | sk-n-mc | ret proto-oncogene | Homo sapiens |
| 3 | RESULTS: The activation of RET9 and RET51 in the SK-N-MC cells significantly reduced the doxorubicin-induced apoptosis by 50%, compared to untreated cells. | sk-n-mc | ret proto-oncogene | Homo sapiens |
| 4 | CONCLUSION: In SK-N-MC cells, downstream activation of MAP kinase, by both RET9 and RET51, appears to mediate the majority of RET-dependent resistance to chemotherapeutically induced apoptosis. | sk-n-mc | ret proto-oncogene | Homo sapiens |
| 5 | CONCLUSION: In SK-N-MC cells, downstream activation of MAP kinase, by both RET9 and RET51, appears to mediate the majority of RET-dependent resistance to chemotherapeutically induced apoptosis. | sk-n-mc | ret proto-oncogene | Homo sapiens |