Title : [Effect of curcumin on the expression of collagen type I protein and transforming growth factor-beta1 mRNA in pulmonary fibrosis rats].

Pub. Date : 2008 May

PMID : 18727865






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The TGF-beta(1) mRNA expression in the curcumin treated group was 0.61 +/- 0.09 and 0.48 +/- 0.16 respectively on the 21(st) and 28(th) day after bleomycin administration (P < 0.05). Bleomycin transforming growth factor, beta 1 Rattus norvegicus
2 CONCLUSION: Curcumin could suppress BLM-induced pulmonary fibrosis in rats at the fibrosing stage, with the possible mechanism of inhibiting the synthesis and deposition of type I collagen protein and depressing the overexpression of TGF-beta(1) mRNA. Bleomycin transforming growth factor, beta 1 Rattus norvegicus