Title : Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.

Pub. Date : 2008 Nov 14

PMID : 18725412






1 Functional Relationships(s)
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1 To avoid the ambiguities of heterogeneous phosphorylation we cloned "pseudo-phosphorylation" mutants of Tau where combinations of Ser or Thr residues were converted into Glu. Glutamic Acid microtubule associated protein tau Homo sapiens