Title : Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.

Pub. Date : 2008 Nov

PMID : 18725385






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Importantly, rendering normal and malignant MECs Cox-2 deficient inhibited their production of PGE(2) and acquisition of an EMT morphology as well as potentiated their nuclear accumulation of Smad2/3 and transcription of plasminogen activator inhibitor-1 and p15 messenger RNA. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens