Title : A TSP-1 functional fragment inhibits activation of latent transforming growth factor-beta1 derived from rat alveolar macrophage after bleomycin treatment.

Pub. Date : 2009 Jan

PMID : 18722097






2 Functional Relationships(s)
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1 A TSP-1 functional fragment inhibits activation of latent transforming growth factor-beta1 derived from rat alveolar macrophage after bleomycin treatment. Bleomycin transforming growth factor, beta 1 Rattus norvegicus
2 Active transforming growth factor-beta1 (TGF-beta1) plays a key role in lung fibrosis induced by bleomycin, TSP-1 (thrombospondin-1) being critical to the activation of L (latent)-TGF-beta1 by virtue of an association of the TSP-1/L-TGF-beta1 complex with CD36, involving the sequence CSVTCG of the TSP-1 functional fragment. Bleomycin transforming growth factor, beta 1 Rattus norvegicus