Title : Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency.

Pub. Date : 2008 Oct 30

PMID : 18721845






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pyrazole can induce CYP2E1 and 2A5, which produce reactive oxygen species (ROS). pyrazole cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
2 Activities and levels of CYP2E1 and 2A5 were elevated by pyrazole in the wild type mice but not in the Nrf2 knockout mice. pyrazole cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus