Title : Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers.

Pub. Date : 2008

PMID : 18721002






1 Functional Relationships(s)
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1 Cinacalcet, as well as some immunosuppressants such as ciclosporin, tacrolimus and sirolimus, is partially metabolized by the cytochrome P450 3A enzymes (CYP3A). Sirolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens