Pub. Date : 2008 Nov
PMID : 18719224
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spermatogonial stem cell self-renewal requires OCT4, a factor downregulated during retinoic acid-induced differentiation. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 2 | In addition to developing a method to test specific gene function in GS cells, we demonstrate that retinoic acid (RA) triggers GS cells to shift to a differentiated, premeiotic state lacking OCT4 and PLZF expression and colonization activity. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 3 | In addition to developing a method to test specific gene function in GS cells, we demonstrate that retinoic acid (RA) triggers GS cells to shift to a differentiated, premeiotic state lacking OCT4 and PLZF expression and colonization activity. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 4 | Our data support a model in which OCT4 and PLZF maintain SSCs in an undifferentiated state and RA triggers spermatogonial differentiation through the direct or indirect downregulation of OCT4 and PLZF. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |