Title : 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.

Pub. Date : 2008 Oct 31

PMID : 18718914






1 Functional Relationships(s)
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1 JNK inhibitor (SP600125) or p38 MAPK inhibitor (SB203580) pretreatment attenuated 15d-PGJ(2)-mediated apoptosis and suppressed the p21(Waf1) and Bax expressions without affecting p53 protein accumulation. pyrazolanthrone BCL2 associated X, apoptosis regulator Homo sapiens