Pub. Date : 2008 Sep
PMID : 18718122
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Many reports have shown that stimulation of the kappa opioid receptor (KOR) suppresses development of analgesic tolerance to morphine. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 2 | Many reports have shown that stimulation of the kappa opioid receptor (KOR) suppresses development of analgesic tolerance to morphine. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 3 | Here, we studied the KOR-mediated inhibition of morphine tolerance during repeated morphine treatment, with a focus on desensitization of the receptor. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 4 | Here, we studied the KOR-mediated inhibition of morphine tolerance during repeated morphine treatment, with a focus on desensitization of the receptor. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 5 | These results indicate that stimulation of KOR caused by repeated morphine treatment either inhibits MOR desensitization or accelerates recycling of MOR on the cell surface, thereby suppressing morphine tolerance. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 6 | These results indicate that stimulation of KOR caused by repeated morphine treatment either inhibits MOR desensitization or accelerates recycling of MOR on the cell surface, thereby suppressing morphine tolerance. | Morphine | opioid receptor kappa 1 | Homo sapiens |
| 7 | These results suggest that the mechanisms underlying KOR-mediated inhibition of analgesic tolerance to morphine may be partly due to suppression of PKC activation and prevention of receptor desensitization. | Morphine | opioid receptor kappa 1 | Homo sapiens |