Pub. Date : 2008 Dec
PMID : 18712364
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) in SERT wild-type (+/+), heterozygous (+/-), and -/- mice. | 5-Hydroxytryptophan | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Mus musculus |
| 2 | OBJECTIVES: To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) in SERT wild-type (+/+), heterozygous (+/-), and -/- mice. | 5-Hydroxytryptophan | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Mus musculus |
| 3 | Behaviorally, 5-HTP induced exaggerated serotonin syndrome behaviors in SERT-/-, mice with similar effects in male and female mice. | 5-Hydroxytryptophan | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Mus musculus |
| 4 | Physiologically, 5-HTP induced exaggerated temperature effects in SERT-deficient mice. | 5-Hydroxytryptophan | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Mus musculus |
| 5 | The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only. | 5-Hydroxytryptophan | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Mus musculus |