Pub. Date : 2008 Oct 17
PMID : 18706914
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of a dimeric intermediate in the unfolding pathway for the calcium-binding protein S100B. | Calcium | S100 calcium binding protein B | Homo sapiens |
| 2 | One member of this family, S100B, is a homodimeric protein shown to control the assembly of several cytoskeletal proteins and regulate phosphorylation events in a calcium-sensitive manner. | Calcium | S100 calcium binding protein B | Homo sapiens |
| 3 | Calcium binding to S100B causes a conformational change involving movement of helix III in the second calcium-binding site (EF2) that exposes a hydrophobic surface enabling interactions with other proteins such as tubulin and Ndr kinase. | Calcium | S100 calcium binding protein B | Homo sapiens |
| 4 | Calcium binding to S100B causes a conformational change involving movement of helix III in the second calcium-binding site (EF2) that exposes a hydrophobic surface enabling interactions with other proteins such as tubulin and Ndr kinase. | Calcium | S100 calcium binding protein B | Homo sapiens |
| 5 | In this work, we have examined the guanidine hydrochloride (GuHCl)-induced unfolding of dimeric calcium-free S100B. | Calcium | S100 calcium binding protein B | Homo sapiens |
| 6 | Together these observations show that calcium-free S100B unfolds via a dimeric intermediate. | Calcium | S100 calcium binding protein B | Homo sapiens |