Title : Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia.

Pub. Date : 2008 Sep

PMID : 18703227






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human equilibrative nucleoside transporters 1 (hENT1) and hENT2 are crucial to maintain physiological plasma levels of adenosine, thus modulating its several biological effects through adenosine receptor activation. Adenosine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 hPMEC from pre-eclampsia exhibit increased total transport (hENT1+hENT2), and maximal velocity (Vmax) for hENT2- (2-fold), but reduced Vmax for hENT1-mediated adenosine transport (75%), with no changes in apparent Km. Adenosine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens