Title : Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5.

Pub. Date : 2008 Oct 1

PMID : 18703135






2 Functional Relationships(s)
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1 Furthermore, we found that Cd-induced ROS inhibited serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5), leading to activation of Erk1/2 and JNK, which was abrogated by NAC. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
2 The results indicate that Cd induction of ROS inhibits PP2A and PP5, leading to activation of JNK and Erk1/2 pathways, and consequently resulting in caspase-dependent and -independent apoptosis of neuronal cells. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens