Title : Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model.

Pub. Date : 2008 Sep

PMID : 18699933






3 Functional Relationships(s)
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1 Dexamethasone was also shown to mitigate eotaxin-mediated migration and IL-5 or eotaxin-promoted differentiation of CD34(+) progenitor cells ex vivo, which were associated with the down-regulation of CCR3 expression on bone marrow progenitor cells. Dexamethasone chemokine (C-C motif) ligand 11 Mus musculus
2 Dexamethasone was also shown to mitigate eotaxin-mediated migration and IL-5 or eotaxin-promoted differentiation of CD34(+) progenitor cells ex vivo, which were associated with the down-regulation of CCR3 expression on bone marrow progenitor cells. Dexamethasone chemokine (C-C motif) ligand 11 Mus musculus
3 CONCLUSIONS: Treatment with anti-CCR3 or dexamethasone can inhibit the migration and differentiation of CD34(+) progenitor cells by regulating the eotaxin/CCR3 axis in asthmatic mice. Dexamethasone chemokine (C-C motif) ligand 11 Mus musculus