Title : Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression.

Pub. Date : 2008 Sep

PMID : 18698233






1 Functional Relationships(s)
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1 METHODS AND RESULTS: In cells expressing the 299D-399T TLR4, LPS activated the transcription factor NFkappaB and increased the expression of interleukin-6 and tumor necrosis factor-alpha, and these effects were reduced by pretreatment of the cells with pravastatin or simvastatin. Simvastatin toll like receptor 4 Homo sapiens