Pub. Date : 2008 Oct 10
PMID : 18697746
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. | Galactose | carbohydrate sulfotransferase 3 | Homo sapiens |
| 2 | In this study, we investigated whether a recombinant human chondroitin 6-sulfotransferase-1 (C6ST-1) catalyzes the sulfation of C6 on both galactose residues in the linkage region using structurally defined acceptor substrates. | Galactose | carbohydrate sulfotransferase 3 | Homo sapiens |
| 3 | In this study, we investigated whether a recombinant human chondroitin 6-sulfotransferase-1 (C6ST-1) catalyzes the sulfation of C6 on both galactose residues in the linkage region using structurally defined acceptor substrates. | Galactose | carbohydrate sulfotransferase 3 | Homo sapiens |
| 4 | Identification of the reaction products obtained with the linkage tetra-, penta-, and hexasaccharide-serines revealed that the C6ST-1 catalyzed the sulfation of C6 on both galactose residues in the linkage region. | Galactose | carbohydrate sulfotransferase 3 | Homo sapiens |
| 5 | Notably, the linkage tetrasaccharide-peptide GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-(Gly)Ser-(Gly-Glu) was a good acceptor substrate for the C6ST-1, suggesting that the sulfation of the galactose residues can occur before the transfer of the first N-acetylhexosamine residue to the linkage tetrasaccharide. | Galactose | carbohydrate sulfotransferase 3 | Homo sapiens |
| 6 | These findings clearly demonstrated that the recombinant C6ST-1 catalyzes the sulfation of C6 on both galactose residues in the linkage region in vitro. | Galactose | carbohydrate sulfotransferase 3 | Homo sapiens |