Title : Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.

Pub. Date : 2008 Oct 17

PMID : 18697738






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Consistent with a block at PC, the most PC-deficient cells showed a metabolic crossover point at PC with increased basal and/or glucose-stimulated pyruvate plus lactate and decreased malate and citrate. malic acid pyruvate carboxylase Homo sapiens
2 Consistent with a block at PC, the most PC-deficient cells showed a metabolic crossover point at PC with increased basal and/or glucose-stimulated pyruvate plus lactate and decreased malate and citrate. malic acid pyruvate carboxylase Homo sapiens
3 In addition, in BCH plus glutamine-stimulated PC knockdown cells, pyruvate plus lactate was increased, whereas citrate was severely decreased, and malate and aspartate were slightly decreased. malic acid pyruvate carboxylase Homo sapiens