Pub. Date : 2008 Oct 24
PMID : 18694926
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |
| 2 | At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |
| 3 | At normoxia two specific proline residues (Pro(402) and Pro(563)) of mHIF-1alpha are hydroxylated and recognized by the von Hippel-Lindau E3 ubiquitin ligase (pVHL) complex, which upon binding mediates degradation of the protein. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |
| 4 | Previous studies have demonstrated that these two proline residues are critical for high affinity binding to pVHL. | Proline | von Hippel-Lindau tumor suppressor | Homo sapiens |