Pub. Date : 2007 Mar-Apr
PMID : 18690019
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that the PKC-induced effects strongly depend on PIP2 levels in the membrane. | Phosphatidylinositol 4,5-Diphosphate | proline rich transmembrane protein 2 | Homo sapiens |
| 2 | At the same time, we show that PKC destabilizes Kir3/PIP2 interactions and enhances the effects of PIP2 depletion on channel activity. | Phosphatidylinositol 4,5-Diphosphate | proline rich transmembrane protein 2 | Homo sapiens |
| 3 | We also show that stabilization of Kir3/PIP2 interactions by Gbetagamma attenuates both PKC and Gq-mediated current inhibition, suggesting that diverse pathways regulate Kir3 activity through modulation of channel interactions with PIP2. | Phosphatidylinositol 4,5-Diphosphate | proline rich transmembrane protein 2 | Homo sapiens |