Title : Toll-like receptor-4 is expressed in meningiomas and mediates the antiproliferative action of paclitaxel.

Pub. Date : 2008 Oct 15

PMID : 18688857






2 Functional Relationships(s)
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1 The suppressive action of paclitaxel on meningioma cell growth was enhanced in the presence of fluvastatin or the mitogen-actvated protein kinase (ERK1/2) inhibitor PD98059. Paclitaxel mitogen-activated protein kinase 3 Homo sapiens
2 In conclusion, our in vitro results suggest that paclitaxel alone or in combination with other inhibitors of cell growth (statins, MAPK inhibitors) could provide a potential tool for the treatment of TLR4 expressing meningiomas. Paclitaxel mitogen-activated protein kinase 3 Homo sapiens