Title : BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins.

Pub. Date : 2008 Aug 1

PMID : 18676837






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 AZD6244 (ARRY 142886) is a potent and selective mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor currently in early clinical trials. AZD 6244 mitogen-activated protein kinase 1 Homo sapiens
2 AZD6244 (ARRY 142886) is a potent and selective mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor currently in early clinical trials. AZD 6244 mitogen-activated protein kinase 1 Homo sapiens