Title : Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.

Pub. Date : 2008 Aug 15

PMID : 18674901






1 Functional Relationships(s)
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1 We studied the synthetic modification of structurally similar N-mercaptoacyl-L-proline and (4R)-N-mercaptoacylthiazolidine-4-carboxylic acid to obtain potent leukotriene A(4) (LTA(4)) hydrolase inhibitors. Leukotriene A4 leukotriene A4 hydrolase Homo sapiens