Pub. Date : 2008 Nov
PMID : 18664592
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Growth arrest and DNA damage inducible (GADD) 153, an ER stress-response gene, is up-regulated after treatment with BG plus cisplatin compared with cisplatin alone in SQ20b and SKOV-3x cells, but not in A549 cells. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Growth arrest and DNA damage inducible (GADD) 153, an ER stress-response gene, is up-regulated after treatment with BG plus cisplatin compared with cisplatin alone in SQ20b and SKOV-3x cells, but not in A549 cells. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Inhibition of ER stress in the SQ20b cell line by salubrinal, an inhibitor of eIF2alpha dephosphorylation, or GADD153 small interfering RNA, abrogated BG-enhancement of cisplatin cytotoxicity and apoptosis through caspase 3 and 12 cleavage. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | These data indicate GADD153 up-regulation plays an important role in BG-enhanced cisplatin cytotoxicity and apoptosis. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |