Title : Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines.

Pub. Date : 1991 Aug

PMID : 1864979






2 Functional Relationships(s)
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1 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Thymidine interleukin 6 Homo sapiens
2 There was a dose-dependent decrease, however, in [3H]-thymidine uptake in the presence of IL-6 antisense (and not sense) oligodeoxynucleotides; in the presence of 20 microM IL-6 antisense, an 80 and 95% inhibition of the proliferation of U 266 and RPMI 8226 cells was observed, respectively. Thymidine interleukin 6 Homo sapiens