Title : Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers.

Pub. Date : 2008 Sep 1

PMID : 18647599






1 Functional Relationships(s)
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1 Flutamide and haloperidol were further demonstrated to cause CYP3A4 induction in human cryopreserved hepatocytes based on testosterone 6beta-hydroxylation activity. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens