Title : Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes.

Pub. Date : 2008 Spring

PMID : 18646312






1 Functional Relationships(s)
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1 Strikingly, the p53 G1 checkpoint in G/G cells was activated by Nutlin-3 but not by etoposide, whereas in other Mdm2-overexpressing cells, both drugs activated p53 and subsequent G1 arrest or apoptosis. nutlin 3 tumor protein p53 Homo sapiens