Title : Activation of MAPK participates in low shear stress-induced IL-8 gene expression in endothelial cells.

Pub. Date : 2008

PMID : 18639962






1 Functional Relationships(s)
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1 Inhibition of ERK1/2, JNK1/2 and p38 MAPK with PD98059, SP600125 and SB203580, respectively, led to the suppression of the shear stress-induced IL-8 gene expression (P<0.01), which was also blocked by JNK1/2 siRNA (small interfering RNA) (P<0.01). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one C-X-C motif chemokine ligand 8 Homo sapiens