Title : The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR.

Pub. Date : 2008 Aug

PMID : 18636161






2 Functional Relationships(s)
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1 The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR. Glutathione mitogen-activated protein kinase 8 Homo sapiens
2 Therefore, the induction of apoptosis by treatment of HepG2 with GSH-DXR was enhanced, thereby facilitating the release of cytochrome c by both deamidated inactivation of Bcl-xL and functional translocation of Bax to the mitochondria via JNK activation. Glutathione mitogen-activated protein kinase 8 Homo sapiens