Title : Prostaglandin analogue misoprostol attenuates neurotoxin 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells.

Pub. Date : 2008 Nov 25

PMID : 18602972






1 Functional Relationships(s)
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1 Treatment with misoprostol significantly attenuated the MPP(+)-induced mitochondrial membrane permeability change that leads to the increase in pro-apoptotic Bax and Cytochrome c levels, and subsequent caspase-3 activation. Misoprostol BCL2 associated X, apoptosis regulator Rattus norvegicus