Pub. Date : 2008 Sep 5
PMID : 18602894
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin down-regulates LDL-receptor expression independently of SREBP-2. | Sirolimus | low density lipoprotein receptor | Homo sapiens |
| 2 | However, LDL-receptor gene expression was decreased by rapamycin, suggesting that this may contribute to the hyperlipidaemia observed in rapamycin-treated patients. | Sirolimus | low density lipoprotein receptor | Homo sapiens |
| 3 | However, LDL-receptor gene expression was decreased by rapamycin, suggesting that this may contribute to the hyperlipidaemia observed in rapamycin-treated patients. | Sirolimus | low density lipoprotein receptor | Homo sapiens |
| 4 | Rapamycin did not affect mRNA stability, so the decrease in LDL-receptor gene expression is likely to be occurring at the transcriptional level, although independently of SREBP-2. | Sirolimus | low density lipoprotein receptor | Homo sapiens |