Pub. Date : 2008 Sep
PMID : 18595723
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To explore lithium"s mechanism of action, we focused on kinase signaling systems (ERK, Akt, JNK) that are believed to play a regulatory role in cell survival, and found that very rapidly after ethanol administration there is a suppression of ERK phosphorylation, and that lithium stimulates ERK phosphorylation and prevents ethanol from suppressing this phosphorylation process. | Ethanol | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We also found that ethanol activates the JNK system, but this cannot explain the neurotoxic action of ethanol, because JNK activation did not occur in the same neuronal populations that are killed by ethanol. | Ethanol | mitogen-activated protein kinase 8 | Homo sapiens |