Title : S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis.

Pub. Date : 2008 Aug 29

PMID : 18591246






2 Functional Relationships(s)
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1 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. Phosphatidylcholines phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C
2 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. Phosphatidylcholines phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C