Title : A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity.

Pub. Date : 2008 Aug

PMID : 18586825






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 APE1/Ref-1 has redox activity and AP endonuclease activity, and is able to enhance DNA-binding activity of several transcription factors, including NF-kappaB, AP-1 and p53, through reduction of their critical cysteine residues. Cysteine tumor protein p53 Homo sapiens