Pub. Date : 2008 Nov
PMID : 18583386
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | It has been demonstrated previously that hCYP1B1 is inhibited by dioxin-like PCBs, but whether or not it is uncoupled has not been investigated. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 4 | In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 5 | These data identify a novel mechanism of genotoxicity for dioxin-like PCBs, as well as providing further evidence that overexpression of hCYP1B1 is a risk factor for extrahepatic carcinogenesis. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |