Pub. Date : 2008 Aug 13
PMID : 18582539
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin. | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 2 | This study evaluated the hypothesis that TNFalpha increases the sensitivity of rat trigeminal neurons to capsaicin via two different mechanisms triggered by either brief or sustained exposure to the cytokine. | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 3 | A brief (5 min) application of TNFalpha significantly sensitized capsaicin-evoked accumulation of intracellular calcium ([Ca2+]i) (226.4+/-37.7 nM vs. 167.5+/-31.3 nM) and increased capsaicin-evoked nocifensive behavior (78.3+/-9.7 vs. 30.9+/-3.6 s) as compared with vehicle pretreatment (P<0.01 for both). | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 4 | A brief (5 min) application of TNFalpha significantly sensitized capsaicin-evoked accumulation of intracellular calcium ([Ca2+]i) (226.4+/-37.7 nM vs. 167.5+/-31.3 nM) and increased capsaicin-evoked nocifensive behavior (78.3+/-9.7 vs. 30.9+/-3.6 s) as compared with vehicle pretreatment (P<0.01 for both). | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 5 | This long-term up-regulation of TRPV1 expression by TNFalpha correlated with enhancement in capsaicin-induced calcitonin gene-related peptide release (P<0.05). | Capsaicin | tumor necrosis factor | Rattus norvegicus |
| 6 | In summary, our data demonstrate that TNFalpha directly enhances the sensitivity of rat trigeminal neurons to capsaicin via both rapid, non-genomic mechanisms as well as sustained genomic regulation in TRPV1 expression. | Capsaicin | tumor necrosis factor | Rattus norvegicus |