Title : TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis.

Pub. Date : 2008 Aug

PMID : 18579711






2 Functional Relationships(s)
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1 Inflammation was induced in the ear skin with five topical applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and a significantly increased inflammation was found in TPA-induced K14/VEGF transgenic animals compared with wild-type mice. Tetradecanoylphorbol Acetate vascular endothelial growth factor A Mus musculus
2 In conclusion, the TPA-induced phenotype in K14/VEGF animals displayed several features of psoriasis, including a T(h)17 cytokine profile and a chronic-like progression, and can be used as an in vivo screening model of psoriasis. Tetradecanoylphorbol Acetate vascular endothelial growth factor A Mus musculus