Title : Chagasic antibodies induce cardiac COX-2/iNOS mRNA expression with PGE2/NO production.

Pub. Date : 2009 May 15

PMID : 18579232






1 Functional Relationships(s)
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1 We demonstrate that serum IgG in chagasic patients interacting with the second extracellular loop of human cardiac M(2) muscarinic acetylcholine receptors (M(2) mAChR) trigger the production of PGE(2) and NO, that in turn induces COX-2/iNOS mRNA expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens