Pub. Date : 2008 Jul 1
PMID : 18577586
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that the inflammatory response and subsequent development of pulmonary fibrosis after inhalation of silica is dependent on the Nalp3 inflammasome. | Silicon Dioxide | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Stimulation of macrophages with silica results in the activation of caspase-1 in a Nalp3-dependent manner. | Silicon Dioxide | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Macrophages deficient in components of the Nalp3 inflammasome were incapable of secreting the proinflammatory cytokines interleukin (IL)-1beta and IL-18 in response to silica. | Silicon Dioxide | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Activation of the Nalp3 inflammasome by silica required both an efflux of intracellular potassium and the generation of reactive oxygen species. | Silicon Dioxide | NLR family pyrin domain containing 3 | Homo sapiens |