Title : Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy.

Pub. Date : 2008 Jul

PMID : 18571549






1 Functional Relationships(s)
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1 Nonetheless, sulphonylurea treatment should be tried in patients with GCK-PNDM, particularly those with mutations resulting in less severe kinetic defects, in whom improved glycemic control may be obtained with lower doses of insulin. Sulfonylurea Compounds insulin Homo sapiens