Title : Phospholipase D activity in human platelets is inhibited by protein kinase A, involving inhibition of phospholipase D1 translocation.

Pub. Date : 2008 Jun

PMID : 18569866






2 Functional Relationships(s)
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1 We found that both PGE(1) and forskolin inhibited thrombin-induced PLD activation by 40-50%, but interestingly PGE(1) caused a modest elevation of PLD activity in resting platelets. Colforsin coagulation factor II, thrombin Homo sapiens
2 We found that PGE(1), forskolin and the PKA activator inhibited PLD1 translocation in thrombin-stimulated platelets, and that the PKG-activator had no effect. Colforsin coagulation factor II, thrombin Homo sapiens