Title : Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors.

Pub. Date : 2008 Nov

PMID : 18568343






1 Functional Relationships(s)
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1 RESULTS: Mycophenolic acid dose-corrected trough concentrations were 60% higher in subjects heterozygous or homozygous for UGT1A8*2 than in those with the wild type (p = 0.02); however, this effect was dependent on concomitant calcineurin inhibitor. Mycophenolic Acid UDP glucuronosyltransferase family 1 member A8 Homo sapiens