Pub. Date : 2008 Aug
PMID : 18567710
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 2 | In the presence of Tiron and polyethylene glycol (PEG)-catalase, known to reduce the level of superoxide anion and hydrogen peroxide (H(2)O(2)), second applications of Ang II evoked similarly reduced constrictions, even after high-pressure exposure (29% +/- 4% at 10(-8) M). | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 3 | These findings suggest that high pressure, likely via inducing H(2)O(2) production, increases the functional availability of AT1 receptors and thus enhances Ang II-induced arteriolar constrictions. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |