Pub. Date : 2008 Jul 1
PMID : 18565825
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion. | Tyrosine | annexin A2 | Homo sapiens |
| 2 | In a cellular model system for tyrosine phosphorylation-based growth factor signaling, we observed that annexin A2 is tyrosine-phosphorylated upon insulin receptor activation. | Tyrosine | annexin A2 | Homo sapiens |
| 3 | In a cellular model system for tyrosine phosphorylation-based growth factor signaling, we observed that annexin A2 is tyrosine-phosphorylated upon insulin receptor activation. | Tyrosine | annexin A2 | Homo sapiens |
| 4 | These morphological changes are inhibited by annexin A2 depletion and require Rho/ROCK signaling downstream of tyrosine-phosphorylated annexin A2. | Tyrosine | annexin A2 | Homo sapiens |
| 5 | Thus, a tyrosine phosphorylation switch in annexin A2 is an important event in triggering Rho/ROCK-dependent and actin-mediated changes in cell morphology associated with the control of cell adhesion. | Tyrosine | annexin A2 | Homo sapiens |