Title : Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.

Pub. Date : 2008 Jun 19

PMID : 18565210






1 Functional Relationships(s)
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1 BACKGROUND: The pyridoxal-5"-phosphate (PLP)-dependent or vitamin B6-dependent enzymes that catalyze manifold reactions in the metabolism of amino acids belong to no fewer than four evolutionarily independent protein families. Vitamin B 6 pyridoxal phosphatase Homo sapiens