Pub. Date : 2008 Jun
PMID : 18562577
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen peroxide induces the production of tumor necrosis factor-alpha in RAW 264.7 macrophage cells via activation of p38 and stress-activated protein kinase. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 2 | The effect of hydrogen peroxide (H(2)O(2)) on production of tumor necrosis factor (TNF)-alpha was examined in RAW 264.7 murine macrophage cells. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 3 | H(2)O( 2) led to production of TNF-alpha up to 24 h after the treatment, but not nitric oxide in RAW 264.7 cells. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 4 | H(2)O(2) induced TNF-alpha production in mouse peritoneal macrophages as well as RAW 264.7 cells. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 5 | Ebselen, a cell permeable antioxidant, prevented the H( 2)O(2)-induced TNFalpha production. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |
| 6 | Therefore, H( 2) O(2) was suggested to induce TNF-alpha production in macrophages via activating p38 and SAPK/JNK as oxidative stress-related signal pathways. | Hydrogen Peroxide | tumor necrosis factor | Mus musculus |