Pub. Date : 2008 Aug 13
PMID : 18562017
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we examined the impact of morphine on IFN-alpha expression in human neuronal cells (NT2-N). | Morphine | interferon alpha 1 | Homo sapiens |
| 2 | IFN-alpha expression in NT2-N cells, however, was inhibited by morphine. | Morphine | interferon alpha 1 | Homo sapiens |
| 3 | Naltrexone antagonized the inhibitory effect of morphine on IFN-alpha expression in NT2-N cells. | Morphine | interferon alpha 1 | Homo sapiens |
| 4 | The specific mu opioid receptor antagonist, Cys2, Tyr3, Arg5, Pen7-amide (CTAP), also blocked the morphine action on intracellular IFN-alpha expression. | Morphine | interferon alpha 1 | Homo sapiens |
| 5 | Investigation of the mechanisms involved in the morphine action showed that although morphine had little effect on the expression of key IFN regulatory factors (IRFs), morphine inhibited IFN-alpha promoter activation and suppressed the expression and phosphorylation of signal transducer and activator of transcription 1 (STAT1) in the neuronal cells. | Morphine | interferon alpha 1 | Homo sapiens |