Title : Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH1 cells: evidence for the accumulation of a rate limiting RNA species in the induction process.

Pub. Date : 1976 Oct

PMID : 185609






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 L-Triiodothyronine stimulated synthetic rates of growth hormone by 1.5-fold in 1.25 hr, 2-fold in 2.5 hr, to a maximal of 3- to 4-fold after 8.5 hr of incubation. Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
2 The time interval between significant L-triiodothyronine binding to putative nuclear receptors and a detectable increase in growth hormone synthesis was 45-60 min. Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
3 Studies on the effect of actinomycin D, 3"-deoxyadenosine, and cycloheximide support the thesis that L-triiodothyronine induces the accumulation of an RNA species which is rate limiting for growth hormone synthesis and lends further support for a primary action of thyroid hormone at the nuclear level. Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus