Title : Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy.

Pub. Date : 2008 Jun 18

PMID : 18560594






1 Functional Relationships(s)
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1 Aldehyde dehydrogenase 1 gene expression and enzymatic activity are elevated in CoCSC and using an in vitro culture system that maintains CoCSC as demonstrated by serial transplants and lentiviral marking of single cell-derived clones, we further show that ALDH1 enzymatic activity is a major mediator of resistance to cyclophosphamide: a classical chemotherapeutic agent. Cyclophosphamide aldehyde dehydrogenase 1 family member A1 Homo sapiens